ISCOMs and immunostimulation with viral antigens.

@article{Hglund1989ISCOMsAI,
  title={ISCOMs and immunostimulation with viral antigens.},
  author={Stefan H{\"o}glund and Kristian Dalsgaard and Kurt Ingmar Loevgren and B G Sundquist and A Osterhaus and Bror Morein},
  journal={Sub-cellular biochemistry},
  year={1989},
  volume={15},
  pages={
          39-68
        }
}
With the dissection of microorganisms followed by biochemical and immunological characterization, antigens inducing protective immunity became recognized. Early attempts to use these isolated antigens as vaccines, i.e. subunit vaccines, showed that although immunogenic in situ as part of the microorganism, they were not immunogenic as purified antigens. Subsequent studies showed that the formation of antigen into defined multimeric forms such as protein micelles or into liposomes made them… CONTINUE READING

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ISCOMs: an adjuvant with multiple functions.

  • Journal of leukocyte biology
  • 1998
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