ISCOM-based vaccines: the second decade.

  title={ISCOM-based vaccines: the second decade.},
  author={Megan T. Sanders and Lorena Elizabeth Brown and Georgia Deliyannis and Martin John Pearse},
  journal={Immunology and cell biology},
  volume={83 2},
The immunostimulating complex or 'iscom' was first described 20 years ago as an antigen delivery system with powerful immunostimulating activity. Iscoms are cage-like structures, typically 40 nm in diameter, that are comprised of antigen, cholesterol, phospholipid and saponin. ISCOM-based vaccines have been shown to promote both antibody and cellular immune responses in a variety of experimental animal models. This review focuses on the evaluation of ISCOM-based vaccines in animals over the… CONTINUE READING

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