IS1 is involved in deletion formation in the gal region of E. coli K12

  title={IS1 is involved in deletion formation in the gal region of E. coli K12},
  author={H. J. Reif and Heinz Saedler},
  journal={Molecular and General Genetics MGG},
The DNA sequence IS1, which is 800 pairs long, has been shown to integrate into various bacterial and phage operons. The presence of this DNA sequence in the gal operon of E. coli K12 leads to an 30–2000 fold increase in deletion formation in the gal region as compared to wildtype. This high frequency of deletion formation is specific for IS1 and is independent of the cellular recA function. While the frequency of reversion of gal::IS1 mutations, which also is independent of recA, is not… CONTINUE READING

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