IS THE POPULATION SIZE OF A SPECIES RELEVANT TO ITS EVOLUTION?

@article{Gillespie2001ISTP,
  title={IS THE POPULATION SIZE OF A SPECIES RELEVANT TO ITS EVOLUTION?},
  author={John H. Gillespie},
  journal={Evolution},
  year={2001},
  volume={55}
}
Abstract This paper examines aspects of genetic draft, the stochastic force induced by substitutions at one locus on the dynamics of a closely linked locus. Of particular interest is the role of population size on genetic draft. Remarkably, the rate of substitution of weakly selected advantageous mutations decreases with increasing population size, whereas that for deleterious mutations increases with population size. This dependency on population size is the opposite of that for genetic drift… 
View on Wiley
onlinelibrary.wiley.com
27 Citations
Background Citations
13

27 Citations

Citation Type

Citation Type

How Much Does Ne Vary Among Species?
TLDR
It is estimated that the power of drift varies by a factor of at least 500 between large-Ne and small-Ne species of animals, i.e., an order of magnitude more than the among-species variation in genetic diversity.
The Temporal Dynamics of Background Selection in Nonequilibrium Populations
TLDR
It is found that the relative levels of diversity in BGS and neutral regions vary over time and that the initial dynamics after a population size change are often in the opposite direction of the long-term expected trajectory.
Random Penetrance of Mutations Among Individuals: A New Type of Genetic Drift in Molecular Evolution
  • Xun Gu
  • Biology
    Phenomics
  • 2021
TLDR
The author formulated a new theory of molecular evolution under a random model of penetrance: for any individual with the same mutational genotype, the coefficient of selection is a random variable.
Impact of demography on linked selection in two outcrossing Brassicaceae species
TLDR
Empirically demonstrates how differences in demographic history modulate the impact of selection at linked sites in natural populations.
Population Genomics and Phylogeography
TLDR
How genomic data from avian species have advanced the authors' understanding of each of these five processes is reviewed, including an emphasis on their interactions in shaping contemporary genetic diversity on the scale of whole populations.
The Linked Selection Signature of Rapid Adaptation in Temporal Genomic Data
TLDR
It is demonstrated that temporal genomic data offer opportunities to identify the role of linked selection on genome-wide diversity over short timescales, and can help bridge population genetic and quantitative genetic studies of adaptation.
The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection
TLDR
It is shown that the observed relationships between the rate of crossing over, and the level of synonymous site diversity and rate of adaptive evolution in Drosophila are probably mainly caused by background selection, whereas selective sweeps and population size changes are needed to produce the observed distortions of the site frequency spectrum.
Genetic variation across trophic levels: A test of the correlation between population size and genetic diversity in sympatric desert lizards
TLDR
Contrary to neutral expectations, results from four independent loci showed levels of diversity were usually higher for species with smaller population sizes, suggesting that selective processes may be having an important impact on intraspecific diversity in this reptile community.
Pervasive Linked Selection and Intermediate-Frequency Alleles Are Implicated in an Evolve-and-Resequencing Experiment of Drosophila simulans
TLDR
Analytical and simulation tools for evolve-and-resequencing experiments are developed and applied to a new study of rapid evolution in Drosophila simulans and SNPs showing strong parallel evolution in the experiment are intermediate in frequency in the natural population indicative of balancing selection in nature.
Dissecting the Effects of Selection and Mutation on Genetic Diversity in Three Wood White (Leptidea) Butterfly Species
TLDR
It was showed that genome-wide diversity and rate of adaptive substitutions were comparatively low, whereas nonsynonymous to synonymous polymorphism and substitution levels were comparatively high in Leptidea, suggesting small long-term effective population sizes, and a significant effect of mutation rate variation on levels of polymorphism.
...
1
2
3
...

References

SHOWING 1-10 OF 33 REFERENCES
Should we expect substitution rate to depend on population size?
TLDR
An alternative model, presented here, predicts the near absence of a population size effect on substitution rate, based on concave log-fitness functions and a fixed distribution of mutational effects on the selectively important trait.
Theoretical study of near neutrality. I. Heterozygosity and rate of mutant substitution.
TLDR
In order to clarify the nature of "near neutrality" in molecular evolution and polymorphism, extensive simulation studies were performed, and it is shown that the larger the population size, the more effective the selection becomes.
The neutral theory in an infinite population.
TLDR
The fact that heterozygosities in natural populations are only weakly dependent on population size suggests that genetic draft may be a much more important stochastic force than genetic drift innatural populations.
The effect of background selection against deleterious mutations on weakly selected, linked variants.
TLDR
The properties of sex-linked and autosomal loci in random-mating populations are compared, and the effects of background selection on asexual and self-fertilizing populations are considered.
The effect of deleterious mutations on neutral molecular variation.
TLDR
Observed reductions in molecular variation in low recombination genomic regions of sufficiently large size, for instance in the centromere-proximal regions of Drosophila autosomes or in highly selfing plant populations, may be partly due to background selection against deleterious mutations.
Genetic drift in an infinite population. The pseudohitchhiking model.
TLDR
The pseudohitchhiking model is a one-locus model that approximates these effects and can be used to describe the major consequences of linked selection, and some results on substitution processes are presented that use the theory of continuous-time Markov processes with discontinuous sample paths.
The hitch-hiking effect of a favourable gene.
TLDR
If the selective coefficients at the linked locus are small compared to those at the substituted locus, it is shown that the probability of complete fixation at thelinked locus is approximately exp (— Nc), where c is the recombinant fraction and N the population size.
The accumulation of deleterious genes in a population--Muller's Ratchet.
  • J. Haigh
  • Biology, Medicine
    Theoretical population biology
  • 1978
TLDR
It is shown that, for a given net rate of arrisal of deleterious mutations, the more the rate of beneficial mutation, the greater the chance that beneficial mutations will accumulate.
The "hitchhiking effect" revisited.
TLDR
A stochastic, finite population model is developed that describes the steady state effect of hitchhiking on the distribution of the number of selectively neutral polymorphic sites in a random sample.
SUBSTITUTION PROCESSES IN MOLECULAR EVOLUTION. II. EXCHANGEABLE MODELS FROM POPULATION GENETICS
  • J. Gillespie
  • Biology, Medicine
    Evolution; international journal of organic evolution
  • 1994
TLDR
The rate of substitution is shown to be remarkably insensitive to the strength of selection for models with strong balancing selection caused by the genealogical drift of mutations through alleles held in the population by selection.
...
1
2
3
4
...