IS-98-ST1 West Nile Virus Derived from an Infectious cDNA Clone Retains Neuroinvasiveness and Neurovirulence Properties of the Original Virus

@inproceedings{Bahuon2012IS98ST1WN,
  title={IS-98-ST1 West Nile Virus Derived from an Infectious cDNA Clone Retains Neuroinvasiveness and Neurovirulence Properties of the Original Virus},
  author={C{\'e}line Bahuon and Philippe C Despr{\'e}s and Nathalie Pardigon and J N Panthier and Nathalie Cordonnier and Steeve Lowenski and Jennifer P. Richardson and St{\'e}phan Zientara and Sylvie Lecollinet},
  booktitle={PloS one},
  year={2012}
}
Infectious clones of West Nile virus (WNV) have previously been generated and used to decipher the role of viral proteins in WNV virulence. The majority of molecular clones obtained to date have been derived from North American, Australian, or African isolates. Here, we describe the construction of an infectious cDNA clone of a Mediterranean WNV strain, IS-98-ST1. We characterized the biological properties of the recovered recombinant virus in cell culture and in mice. The growth kinetics of… CONTINUE READING

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