IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.

@article{Nguyen2012IRX4A5,
  title={IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.},
  author={Hai Ha Nguyen and Ryo Takata and Shusuke Akamatsu and Daichi Shigemizu and Tatsuhiko Tsunoda and Mutsuo Furihata and Atsushi Takahashi and Michiaki Kubo and Naoyuki Kamatani and Osamu Ogawa and Tomoaki Fujioka and Yusuke Nakamura and Hidewaki Nakagawa},
  journal={Human molecular genetics},
  year={2012},
  volume={21 9},
  pages={
          2076-85
        }
}
Recent genome-wide association studies (GWAS) identified a number of prostate cancer (PC) susceptibility loci, but most of their functional significances are not elucidated. Through our previous GWAS for PC in a Japanese population and subsequent resequencing and fine mapping, we here identified that IRX4 (Iroquois homeobox 4), coding Iroquois homeobox 4, is a causative gene of the PC susceptibility locus (rs12653946) at chromosome 5p15. IRX4 is expressed specifically in the prostate and heart… 
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The data indicate that the PC genome is more complex and heterogeneous than the authors expected from GWAS and sequencing analyses.
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