IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.

@article{Miller2002IRTAsAN,
  title={IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.},
  author={Ira D. Miller and Georgia Hatzivassiliou and Giorgio Cattoretti and Cathy Mendelsohn and Riccardo Dalla-Favera},
  journal={Blood},
  year={2002},
  volume={99 8},
  pages={
          2662-9
        }
}
The IRTA1 and IRTA2 genes encode immunoglobulinlike cell surface receptors expressed in B cells and involved in chromosome 1q21 translocations in B-cell malignancy. We have now characterized and comparatively analyzed the structure and expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome 1q21. The IRTA messenger RNAs are expressed predominantly in the B-cell lineage within discrete B-cell compartments: IRTA1 is specific to the… CONTINUE READING
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