IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.

@article{Weiss2009IRSp53LT,
  title={IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.},
  author={Stefanie M Weiss and Markus Ladwein and Dorothea F Schmidt and Julia Ehinger and Silvia Lommel and Kai St{\"a}ding and Ulrike Beutling and Andrea Disanza and Ronald F Frank and Lothar J{\"a}nsch and Giorgio Scita and Florian Gunzer and Klemens Rottner and Theresia Stradal},
  journal={Cell host & microbe},
  year={2009},
  volume={5 3},
  pages={244-58}
}
Actin pedestal formation by pathogenic E. coli requires signaling by the bacterial intimin receptor Tir, which induces host cell actin polymerization mediated by N-WASP and the Arp2/3 complex. Whereas canonical enteropathogenic E. coli (EPEC) recruit these actin regulators through tyrosine kinase signaling cascades, enterohemorrhagic E. coli (EHEC) O157:H7 employ the bacterial effector EspF(U) (TccP), a potent N-WASP activator. Here, we show that IRSp53 family members, key regulators of… CONTINUE READING

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