IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.

Abstract

IRSp53 has been characterized as an adaptor protein that links Rho-family small GTPases, such as Rac, to reorganization of the actin cytoskeleton. Here, we search for other binding partners for the IRSp53 SH3 domain and identify Eps8 as the major binding protein in fibroblasts and various cancer cell lines. Eps8 has been shown to form a Rac-specific guanine… (More)

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Cite this paper

@article{Funato2004IRSp53Eps8CI, title={IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.}, author={Yosuke Funato and Takeshi Terabayashi and Naoko Suenaga and Motoharu Seiki and Tadaomi Takenawa and Hiroaki Miki}, journal={Cancer research}, year={2004}, volume={64 15}, pages={5237-44} }