IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.

@article{Sadagurski2012IRS2SI,
  title={IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.},
  author={Marianna Sadagurski and Rebecca L. Leshan and Christa M. Patterson and Aldo Rozzo and Alexandra Kuznetsova and Josh C. Skorupski and Justin C. Jones and Ronald A DePinho and Martin G Myers and Morris F. White},
  journal={Cell metabolism},
  year={2012},
  volume={15 5},
  pages={
          703-12
        }
}
Irs2-mediated insulin/IGF1 signaling in the CNS modulates energy balance and glucose homeostasis; however, the site for Irs2 function is unknown. The hormone leptin mediates energy balance by acting on leptin receptor (LepR-b)-expressing neurons. To determine whether LepR-b neurons mediate the metabolic actions of Irs2 in the brain, we utilized Lepr(cre) together with Irs2(L/L) to ablate Irs2 expression in LepR-b neurons (Lepr(ΔIrs2)). Lepr(ΔIrs2) mice developed obesity, glucose intolerance… CONTINUE READING

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