IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates

@article{Russo2007IRS2AktPI,
  title={IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates},
  author={Scott J Russo and Carlos A. Bola{\~n}os and David E. H. Theobald and Nathan A Decarolis and William Renthal and Arvind Kumar and Catharine A. Winstanley and Nora E. Renthal and Matthew D. Wiley and David W Self and David Stark Russell and Rachael Lee Neve and Amelia J Eisch and Eric J Nestler},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={93-99}
}
Chronic morphine administration (via subcutaneous pellet) decreases the size of dopamine neurons in the ventral tegmental area (VTA), a key reward region in the brain, yet the molecular basis and functional consequences of this effect are unknown. In this study, we used viral-mediated gene transfer in rat to show that chronic morphine–induced downregulation of the insulin receptor substrate 2 (IRS2)–thymoma viral proto-oncogene (Akt) signaling pathway in the VTA mediates the decrease in… CONTINUE READING
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