IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk

Abstract

BACKGROUND AND AIMS A recent genome-wide association study identified rs2943641C > T, 500 kb from the insulin receptor substrate-1 gene (IRS1), as a type-2 diabetes (T2D) susceptibility locus. We aimed to replicate this association by meta-analysis and examine whether common variants within IRS1, present on the HumanCVD BeadChip, were associated with T2D… (More)
DOI: 10.1016/j.numecd.2011.05.009

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