IRS1 and IRS2: molecular characterization, tissue expression and transcriptional regulation by insulin in yellow catfish Pelteobagrus fulvidraco

@article{Zhuo2016IRS1AI,
  title={IRS1 and IRS2: molecular characterization, tissue expression and transcriptional regulation by insulin in yellow catfish Pelteobagrus fulvidraco},
  author={Mei-Qin Zhuo and Ya-Xiong Pan and Kun Wu and Yi-Huan Xu and Li-Han Zhang and Zhi Luo},
  journal={Fish Physiology and Biochemistry},
  year={2016},
  volume={43},
  pages={619-630}
}
The insulin receptor substrate (IRS) proteins, in particular, IRS1 and IRS2, are the key downstream players of insulin signaling pathway and the regulation of lipid metabolism. In the present study, two genes of IRS (IRS1 and IRS2) were isolated and characterized from yellow catfish Pelteobagrus fulvidraco. Their molecular characterizations, tissue expressions, and transcriptional levels by insulin both in vivo and in vitro were determined. The validated complementary DNAs encoding for IRS1 and… CONTINUE READING