IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.

@article{Uchida2000IRS4MP,
  title={IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.},
  author={Tohru Uchida and Martin G Myers and Morris F. White},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 1},
  pages={126-38}
}
Insulin receptor substrate (IRS) proteins are tyrosine phosphorylated and mediate multiple signals during activation of the receptors for insulin, insulin-like growth factor 1 (IGF-1), and various cytokines. In order to distinguish common and unique functions of IRS-1, IRS-2, and IRS-4, we expressed them individually in 32D myeloid progenitor cells containing the human insulin receptor (32D(IR)). Insulin promoted the association of Grb-2 with IRS-1 and IRS-4, whereas IRS-2 weakly bound Grb-2… CONTINUE READING