IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients.

@article{Bouzakri2006IRS1SP,
  title={IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients.},
  author={Karim Bouzakri and H{\aa}kan K. R. Karlsson and Henrik Vestergaard and Sten Madsbad and Erik Christiansen and Juleen R Zierath},
  journal={Diabetes},
  year={2006},
  volume={55 3},
  pages={785-91}
}
Insulin-dependent diabetic recipients of successful pancreas allografts achieve self-regulatory insulin secretion and discontinue exogenous insulin therapy; however, chronic hyperinsulinemia and impaired insulin sensitivity generally develop. To determine whether insulin resistance is accompanied by altered signal transduction, skeletal muscle biopsies were obtained from pancreas-kidney transplant recipients (n = 4), nondiabetic kidney transplant recipients (receiving the same immunosuppressive… CONTINUE READING

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