IRS-1 gene polymorphism and DNA damage in pregnant women with diabetes or mild gestational hyperglycemia

@inproceedings{Gelaleti2015IRS1GP,
  title={IRS-1 gene polymorphism and DNA damage in pregnant women with diabetes or mild gestational hyperglycemia},
  author={Rafael Bottaro Gelaleti and D{\'e}bora Cristina Damasceno and Daisy Maria F{\'a}vero Salvadori and Jo{\~a}o Paulo Castro Marcondes and Paula Helena Ortiz Lima and Glilciane Morceli and Iracema Mattos Paranhos Calderon and Marilza Vieira Cunha Rudge},
  booktitle={Diabetology & metabolic syndrome},
  year={2015}
}
BACKGROUND Pregnant women with mild gestational hyperglycemia present a high risk for hypertension and obesity, and appear to reproduce the model of metabolic syndrome in pregnancy, including hyperinsulinemia and insulin resistance. Diabetic patients have a higher frequency of the IRS-1 Gly972Arg variant and this polymorphism is directly related to insulin resistance and subsequent hyperglycemia. In diabetes, hyperglycemia and other associated factors generate reactive oxygen species that… CONTINUE READING
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