IRF8-dependent molecular complexes control the Th9 transcriptional program

  title={IRF8-dependent molecular complexes control the Th9 transcriptional program},
  author={Etienne Humblin and Marion Thibaudin and Fanny Chalmin and Valentin D{\'e}rang{\`e}re and Emeric Limagne and Corentin Richard and Richard A Flavell and Sandy Chevrier and Sylvain Ladoire and H{\'e}l{\`e}ne Berger and Romain Boidot and Lionel Apetoh and Fr{\'e}d{\'e}rique V{\'e}gran and François Ghiringhelli},
  booktitle={Nature Communications},
Interferon regulatory factors (IRF) have critical functions in lymphoid development and in immune response regulation. Although many studies have described the function of IRF4 in CD4+ T cells, few have focused on the IRF4 homologue, IRF8. Here, we show that IRF8 is required for Th9 differentiation in vitro and in vivo. IRF8 functions through a transcription factor complex consisting of IRF8, IRF4, PU.1 and BATF, which binds to DNA and boosts Il9 transcription. By contrast, IRF8 deficiency… CONTINUE READING
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