IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.

@article{Yez2015IRF8AI,
  title={IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.},
  author={A. Y{\'a}{\~n}ez and M. Ng and Nargess Hassanzadeh-Kiabi and H. Goodridge},
  journal={Blood},
  year={2015},
  volume={125 9},
  pages={
          1452-9
        }
}
Interferon regulatory factor 8 (IRF8) is a key regulator of myelopoiesis in mice and humans. IRF8-deficient mice exhibit increased neutrophil numbers but defective monocyte and dendritic cell (DC) production. It has therefore been hypothesized that IRF8 regulates granulocyte vs monocyte/DC lineage commitment by oligopotent progenitors. Alternatively, IRF8 could control the differentiation of lineage-committed progenitors. In this study, we defined the role of IRF8 in lineage commitment and… Expand
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