IRF7-dependent IFN-β production in response to RANKL promotes medullary thymic epithelial cell development.

Abstract

The contributions of IFN regulatory factor (IRF) 3/7 and the type I IFNs IFN-α/β to the innate host defense have been extensively investigated; however, their role in thymic development is less clear. In this study, we show that mice lacking the type I IFN receptor IFN-α/β receptor (IFNAR) or the downstream transcription factor STAT1 harbor a significant… (More)
DOI: 10.4049/jimmunol.1203086

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