IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population.

  title={IRF6 is a risk factor for nonsyndromic cleft lip in the Brazilian population.},
  author={Luciano Abreu Brito and Camila Fernandes Silva Bassi and Cibele Masotti and Carolina Malcher and Katia Maria Rocha and David Schlesinger and Daniela Franco Bueno and Lucas Alvizi Cruz and L{\'i}gia Kobayashi B{\'a}rbara and D{\'e}bora Bertola and Diogo Meyer and Diogo Franco and N. Pineda Alonso and Maria Rita Santos Passos-Bueno},
  journal={American journal of medical genetics. Part A},
  volume={158A 9},
Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a complex disorder with a worldwide incidence estimated at 1:700. Among the putative susceptibility loci, the IRF6 gene and a region at 8q24.21 have been corroborated in different populations. To test the role of IRF6 in NSCL/P predisposition in the Brazilian population, we conducted a structured association study with the SNPs rs642961 and rs590223, respectively, located at 5' and 3' of the IRF6 gene and not in strong linkage… CONTINUE READING
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