IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

@article{Krausgruber2011IRF5PI,
  title={IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses},
  author={Thomas Krausgruber and Katrina Blazek and Tim Smallie and Saba Alzabin and Helen E. Lockstone and Natasha Sahgal and Tracy Hussell and Marc Feldmann and Irina A. Udalova},
  journal={Nature Immunology},
  year={2011},
  volume={12},
  pages={231-238}
}
Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases. Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarization. High expression of IRF5 was characteristic of M1 macrophages, in which it directly activated transcription of the genes encoding interleukin 12 subunit p40 (IL-12p40), IL-12p35 and IL-23p19 and… 

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