IRF4 variants have age-specific effects on nevus count and predispose to melanoma.

  title={IRF4 variants have age-specific effects on nevus count and predispose to melanoma.},
  author={David L Duffy and Mark M. Iles and Dan Glass and G. -J. Zhu and Jennifer H. Barrett and Veronica H{\"o}iom and Zhen Zhen Zhao and Richard A Sturm and Nicole Soranzo and Christopher J Hammond and Marina Kvaskoff and David C Whiteman and Massimo Mangino and Johan Hansson and Julia A. Newton-Bishop and V{\'e}ronique Bataille and N. K. Hayward and Nicholas G. Martin and D Timothy Bishop and Tim D. Spector and Grant W. Montgomery},
  journal={American journal of human genetics},
  volume={87 1},
High melanocytic nevus count is a strong predictor of melanoma risk. A GWAS of nevus count in Australian adolescent twins identified an association of nevus count with the interferon regulatory factor 4 gene (IRF4 [p = 6 x 10(-9)]). There was a strong genotype-by-age interaction, which was replicated in independent UK samples of adolescents and adults. The rs12203592(*)T allele was associated with high nevus counts and high freckling scores in adolescents, but with low nevus counts and high… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 52 extracted citations


Publications referenced by this paper.
Showing 1-10 of 46 references

Melanoma epidemiology

  • M. A. Tucker
  • Hematol. Oncol. Clin. North Am
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…