IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.

@article{Huber2008IRF4IE,
  title={IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.},
  author={Magdalena Huber and Anne Br{\"u}stle and Katharina Reinhard and Anna Guralnik and Gina Walter and Azita Josefine Mahiny and Eberhard von L{\"o}w and Michael Lohoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 52},
  pages={20846-51}
}
Differentiation of murine T-helper (Th) 17 cells is induced by antigenic stimulation and the sequential action of the cytokines IL-6, IL-21, and IL-23, along with TGFbeta. Current dogma proposes that IL-6 induces IL-21, which, in a STAT3-dependent manner, amplifies its own transcription, contributes to IL-17 production, and, moreover, promotes the expression of the IL-23 receptor. This, in turn, prepares cells for IL-23-mediated stabilization of the Th17 phenotype. Here we demonstrate that… CONTINUE READING

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