IRF4 addiction in multiple myeloma

  title={IRF4 addiction in multiple myeloma},
  author={Arthur L Shaffer and Neset Cevdet Tolga Emre and Laurence Lamy and Vu N. Ngo and George Wright and Wenming Xiao and John G. Powell and Sandeep Dave and Xin Yu and Haishuang Zhao and Yuxin Zeng and Bangzheng Chen and Joshua Epstein and Louis M. Staudt},
The transcription factor IRF4 (interferon regulatory factor 4) is required during an immune response for lymphocyte activation and the generation of immunoglobulin-secreting plasma cells. Multiple myeloma, a malignancy of plasma cells, has a complex molecular aetiology with several subgroups defined by gene expression profiling and recurrent chromosomal translocations. Moreover, the malignant clone can sustain multiple oncogenic lesions, accumulating genetic damage as the disease progresses… CONTINUE READING
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