IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.

@article{Smith2001IRF3AI,
  title={IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.},
  author={Ewan St John Smith and Isabelle J. Mari{\'e} and Arun J. Prakash and Adolfo Garc{\'i}a-Sastre and David E. Levy},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 12},
  pages={
          8951-7
        }
}
Induction of interferon-alpha (IFNalpha) gene expression in virus-infected cells requires phosphorylation-induced activation of the transcription factors IRF3 and IRF7. However, the kinase(s) that targets these proteins has not been identified. Using a combined pharmacological and genetic approach, we found that none of the kinases tested was responsible for IRF phosphorylation in cells infected with Newcastle disease virus (NDV). Although the broad-spectrum kinase inhibitor staurosporine… CONTINUE READING

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