IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma.

@article{Ramos2007IRF4AC,
  title={IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma.},
  author={Juan Carlos Pena Ramos and Phillip Ruiz and L. S. Ratner and Isildinha M. Reis and Carlos R Brites and C{\'e}lia Pedroso and Gerald E. Byrne and Ngoc L. Toomey and Valentine B Andela and Edward William Harhaj and Izidore S Lossos and William J. Harrington},
  journal={Blood},
  year={2007},
  volume={109 7},
  pages={3060-8}
}
Adult T-cell leukemia/lymphoma (ATLL) is a generally fatal malignancy. Most ATLL patients fare poorly with conventional chemotherapy; however, antiviral therapy with zidovudine (AZT) and interferon alpha (IFN-alpha) has produced long-term clinical remissions. We studied primary ATLL tumors and identified molecular features linked to sensitivity and resistance to antiviral therapy. Enhanced expression of the proto-oncogene c-Rel was noted in 9 of 27 tumors. Resistant tumors exhibited c-Rel (6 of… CONTINUE READING
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IRF-4 AND c-Rel IN ANTIVIRAL-RESISTANT ATLL 3067 BLOOD, 1 APRIL

  • HW Mittrucker, T Matsuyama, A Grossman
  • For personal use only. on April
  • 2007

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