IRF 4 Differentiation through Direct Suppression of That T-bet Controls Th 17 Lineage Genome-Wide Regulatory Analysis Reveals

@inproceedings{Gkmen2013IRF4D,
  title={IRF 4 Differentiation through Direct Suppression of That T-bet Controls Th 17 Lineage Genome-Wide Regulatory Analysis Reveals},
  author={Refik G{\"o}kmen and Rong Dong and Aditi Kanhere and Nick Powell and Esperanza Perucha and Ian Thomas Jackson and Jane K. Howard and Maria P Hernandez-Fuentes and Richard G Jenner},
  year={2013}
}
The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lineage. It has recently been suggested that pathogenic Th17… CONTINUE READING