IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.

  title={IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.},
  author={Jahangir Iqbal and Kezhi Dai and Tracie Seimon and Rivka Jungreis and Miho Oyadomari and George Kuriakose and David Ron and Ira Tabas and M. Mahmood Hussain},
  journal={Cell metabolism},
  volume={7 5},
Microsomal triglyceride transfer protein (MTP) is needed to assemble chylomicrons in the endoplasmic reticulum (ER) of enterocytes. We explored the role of an ER stress protein, inositol-requiring enzyme 1beta (IRE1beta), in regulating this process. High-cholesterol and high-fat diets decreased intestinal IRE1beta mRNA in wild-type mice. Ire1b(-/-) mice fed high-cholesterol and high-fat diets developed more pronounced hyperlipidemia because these mice secreted more chylomicrons and expressed… CONTINUE READING


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