IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.

@article{Lee2012IRE1PA,
  title={IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.},
  author={Huikyong Lee and Jee-Yeon Noh and Yumin Oh and Youngdoo Kim and J W Chang and C W Chung and Sang Kun Lee and Manho Kim and Hoon Ryu and Yong-Keun Jung},
  journal={Human molecular genetics},
  year={2012},
  volume={21 1},
  pages={101-14}
}
Huntington's disease (HD), an inherited neurodegenerative disorder, is caused by an expansion of cytosine-adenine-guanine repeats in the huntingtin gene. The aggregation of mutant huntingtin (mtHTT) and striatal cell loss are representative features to cause uncontrolled movement and cognitive defect in HD. However, underlying mechanism of mtHTT aggregation and cell toxicity remains still elusive. Here, to find new genes modulating mtHTT aggregation, we performed cell-based functional screening… CONTINUE READING
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