IRE1 inhibition affects the expression of insulin-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells.

@article{Minchenko2015IRE1IA,
  title={IRE1 inhibition affects the expression of insulin-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells.},
  author={Dmytro O. Minchenko and Anastasia P. Kharkova and Dariia O. Tsymbal and Leonid L. Karbovskyi and Oleksandr H. Minchenko},
  journal={Endocrine regulations},
  year={2015},
  volume={49 4},
  pages={
          185-97
        }
}
OBJECTIVE The aim of the present study was to investigate the effect of inhibition of endoplasmic reticulum stress signaling mediated by IRE1/ERN1 (inositol-requiring enzyme 1/endoplasmic reticulum to nucleus signaling 1) on the expression of genes encoding different groups of insulin-like growth binding proteins (IGFBP6 and IGFBP7) and CCN family (IGFBP8/CTGF/CCN2, IGFBP9/NOV/CCN3, IGFBP10/CYR61/CCN1, WISP1/CCN4, and WISP2/CCN5) and its sensitivity to glucose deprivation in U87 glioma cells… CONTINUE READING
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