• Corpus ID: 45306485

IRE1 alpha may be causing abnormal loss of p53 at post transcriptional level in chronic myeloid leukemia

@article{Toppaldoddi2017IRE1AM,
  title={IRE1 alpha may be causing abnormal loss of p53 at post transcriptional level in chronic myeloid leukemia},
  author={Katte Rao Toppaldoddi},
  journal={arXiv: Subcellular Processes},
  year={2017}
}
Current treatment strategy for chronic myeloid leukemia (CML) mainly includes inhibition of tyrosine kinase activity, which has dramatically improved the prognosis of the disease but without cure. In addition some patients may become drug resistant. Thus there is still the need for other therapies to avoid resistance and if possible to cure the disease. Loss of p53 is known to play an important role in the disease progression of CML and causes drug resistance. Here I propose that in CML… 
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