IRE1α dissociates with BiP and inhibits ER stress-mediated apoptosis in cartilage development.

Abstract

Bone morphogenetic protein 2 is known to activate unfolded protein response signaling molecules, including XBP1S, BiP and IRE1α. Endoplasmic reticulum stress is induced in chondrogenesis and activates IRE1α signal pathway, which is associated with ER stress-mediated apoptosis. However, the influence on IRE1α and BiP in BMP2-induced chondrocyte… (More)
DOI: 10.1016/j.cellsig.2013.06.011

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