IRD1 and IRD2 mice, naturally occurring models of hereditary retinal dysfunction, show late-onset and progressive retinal degeneration.

PURPOSE To elucidate whether Institute for Cancer Research (ICR) derived retinal dysfunction (IRD) 1 and IRD2 mice, spontaneous mouse models of rod-cone and rod dysfunction, respectively, develop age-related retinal degeneration. MATERIALS AND METHODS Morphological and morphometric examinations were performed in the retinas of both mutants from 1 to 18… CONTINUE READING