IRC011, a new synthetic chelator with selective interaction with catabolic red blood cell iron: evaluation in hypertransfused rats with hepatocellular and reticuloendothelial radioiron probes and in iron-loaded rat heart cells in culture.

@article{Rivkin1997IRC011AN,
  title={IRC011, a new synthetic chelator with selective interaction with catabolic red blood cell iron: evaluation in hypertransfused rats with hepatocellular and reticuloendothelial radioiron probes and in iron-loaded rat heart cells in culture.},
  author={G. Rivkin and G. Link and E. Simhon and R. Cyjon and J. Y. Klein and C. Hershko},
  journal={Blood},
  year={1997},
  volume={90 10},
  pages={
          4180-7
        }
}
  • G. Rivkin, G. Link, +3 authors C. Hershko
  • Published 1997
  • Medicine
  • Blood
  • A major consideration in the selection of new and improved iron chelators for clinical use is preferential interaction with the most toxic iron compartment. We describe the biologic properties of a new synthetic hexadentate iron chelator (IRC011) that is a substituted polyaza compound. Unlike deferoxamine (DF ), the polyaza structure of IRC011 does not contain any readily hydrolyzable covalent bonds and is anticipated to resist in vivo biotransformation. In the present studies, the ability of… CONTINUE READING
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