IRAK4 activation: a cautious embrace.

  title={IRAK4 activation: a cautious embrace.},
  author={Stevan R Hubbard},
  journal={Molecular cell},
  volume={55 6},
Structural and biochemical studies by Ferrao et al. (2014) in this issue demonstrate that dimerization of the kinase domain of IRAK4 is crucial for its activation, but with conditions: after-not before-receptor recruitment and before-not after-autophosphorylation.