IRAK-4-dependent degradation of IRAK-1 is a negative feedback signal for TLR-mediated NF-kappaB activation.

  title={IRAK-4-dependent degradation of IRAK-1 is a negative feedback signal for TLR-mediated NF-kappaB activation.},
  author={Miho Kubo-Murai and K. Hazeki and K. Nigorikawa and Takatoshi Omoto and N. Inoue and O. Hazeki},
  journal={Journal of biochemistry},
  volume={143 3},
  • Miho Kubo-Murai, K. Hazeki, +3 authors O. Hazeki
  • Published 2008
  • Biology, Medicine
  • Journal of biochemistry
  • The activation of interleukin 1 receptor-associated kinase (IRAK)-1 is a key event in the transmission of signals from Toll-like receptors (TLRs). The catalytic activity of the protein kinase is not essential for its ability to activate nuclear factor (NF) kappaB, because transfection of a kinase-dead mutant of IRAK-1 (IRAK-1KD) is able to activate NF-kappaB in HEK293T cells. In the present study, we observed that the effect of IRAK-1KD was impaired by simultaneous expression of IRAK-4. The… CONTINUE READING
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