IRAK-2 Regulates IL-1-Mediated Pathogenic Th17 Cell Development in Helminthic Infection

  title={IRAK-2 Regulates IL-1-Mediated Pathogenic Th17 Cell Development in Helminthic Infection},
  author={Patrick M. Smith and Berri H Jacque and James R Conner and Alexander N. Poltorak and Miguel J. Stadecker},
  booktitle={PLoS pathogens},
Infection with the trematode parasite Schistosoma mansoni results in distinct heterogeneity of disease severity both in humans and in mice. In the experimental mouse model, severe disease is characterized by pronounced hepatic egg-induced granulomatous inflammation mediated by CD4 Th17 cells, whereas mild disease is associated with reduced hepatic inflammation in a Th2-skewed cytokine environment. Even though the host's genetic background significantly impacts the clinical outcome of… CONTINUE READING


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