IRAK-2 Regulates IL-1-Mediated Pathogenic Th17 Cell Development in Helminthic Infection

@inproceedings{Smith2011IRAK2RI,
  title={IRAK-2 Regulates IL-1-Mediated Pathogenic Th17 Cell Development in Helminthic Infection},
  author={Patrick M. Smith and Berri H Jacque and James R Conner and Alexander N. Poltorak and Miguel J. Stadecker},
  booktitle={PLoS pathogens},
  year={2011}
}
Infection with the trematode parasite Schistosoma mansoni results in distinct heterogeneity of disease severity both in humans and in mice. In the experimental mouse model, severe disease is characterized by pronounced hepatic egg-induced granulomatous inflammation mediated by CD4 Th17 cells, whereas mild disease is associated with reduced hepatic inflammation in a Th2-skewed cytokine environment. Even though the host's genetic background significantly impacts the clinical outcome of… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 70 references

The immunobiology of schistosomiasis

Nature Reviews Immunology • 2002
View 16 Excerpts
Highly Influenced

Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling

K Ghoreschi, A Laurence, XP Yang, CM Tato, MJ McGeachy
Nature • 2010
View 1 Excerpt

BATF: bringing (in) another Th17-regulating factor.

Journal of molecular cell biology • 2009
View 2 Excerpts

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