IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.

@article{Antl2007IRAGMN,
  title={IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.},
  author={Melanie Antl and Marie-Luise von Bruehl and Christina Eiglsperger and Matthias Werner and Ildiko Konrad and Thomas Z Kocher and Matthias Wilm and Franz Hofmann and Steffen Massberg and Jens Schlossmann},
  journal={Blood},
  year={2007},
  volume={109 2},
  pages={552-9}
}
Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis, the major complication of atherosclerosis triggering myocardial infarction and stroke. A central regulatory pathway conveying inhibition of platelet activation/aggregation is nitric oxide (NO)/cyclic GMP (cGMP) signaling by cGMP-dependent protein kinase I (cGKI). However, the regulatory cascade downstream of cGKI mediating platelet inhibition is still unclear. Here, we show that the inositol… CONTINUE READING
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