IR TrueFISP with a golden‐ratio‐based radial readout: Fast quantification of T1, T2, and proton density

  title={IR TrueFISP with a golden‐ratio‐based radial readout: Fast quantification of T1, T2, and proton density},
  author={Philipp Ehses and Nicole Seiberlich and Dan Ma and Felix Breuer and Peter M. Jakob and Mark A. Griswold and Vikas Gulani},
  journal={Magnetic Resonance in Medicine},
A promising approach for the simultaneous quantification of relative proton density (M0), T1, and T2 is the inversion‐recovery TrueFISP sequence, consisting of an inversion pulse followed by a series of balanced steady‐state free precession acquisitions. Parameters can then be obtained from a mono‐exponential fit to the series of images. However, a segmented acquisition is usually necessary, which increases the total acquisition time considerably. The goal of this study is to obtain M0, T1, and… 
Single-shot multi-slice T1 mapping at high spatial resolution – Inversion-recovery FLASH with radial undersampling and iterative reconstruction.
Purpose: To develop a method for T1 mapping at high spatial resolution and for multiple slices. Methods: The proposed method emerges as a single-shot inversion-recovery experiment which covers the
Model-Based Acceleration of Look-Locker T1 Mapping
The presented approach represents a promising way for fast and accurate T 1 mapping using radial IR-LL acquisitions without the need of any segmentation.
Silent 3D MR sequence for quantitative and multicontrast T1 and proton density imaging.
This study aims to develop a silent, fast and 3D method for T1 and proton density (PD) mapping, while generating time series of T1-weighted (T1w) images with bias-filed correction. Undersampled T1w
T 1 Measurements in the Human Myocardium: The Effects of Magnetization Transfer on the SASHA and
Quantitative mapping of the native T1 of the heart using the modified look-locker inversion recovery (MOLLI) technique provides high quality diagnostic information without requiring contrast agents and is insensitive to MT and T2, whereas MT reduces the T1 measured by MOLLI in addition to the effects due to T2 relaxation.
Generating multiple contrasts using single‐shot radial T1 sensitive and insensitive steady‐state imaging
The purpose of this work is to present an extension of this technique, considerably increasing both the efficiency and possibilities of TOSSI.
The effect of scan parameters on T1, T2 relaxation times measured with multi-dynamic multi-echo sequence: a phantom study.
Quantitative T1, T2 measurements of gray matter, white matter and cerebrospinal fluid simulation phantoms derived from the MDME sequence were not obviously affected by variations of scanning parameters, such as echo train length, matrix, and acceleration factor on 3T scanner.
Rapid high‐resolution T1 mapping using a highly accelerated radial steady‐state free‐precession technique
A multi‐slice inversion‐recovery (IR) radial steady‐state free precession (radSSFP) pulse sequence combined with a principal component (PC) based reconstruction that overcomes limitations in slice coverage and spatial‐temporal resolution is presented.


Inversion recovery TrueFISP: Quantification of T1, T2, and spin density
It is shown that the ratio T1/T2 can be directly extracted from the inversion factor INV, which describes the relation of the signal value extrapolated to t = 0 and the steady‐state signal.
Novel method for rapid, simultaneous T1, T*2, and proton density quantification
The QRAPTEST method is presented as a means of quickly determining the longitudinal T1 and transverse T  2* relaxation time and proton density within a single sequence and provides a clinical example in which quantification of the whole brain using 1.5 mm3 voxels was achieved in less than 8 min.
Practical Implementation and Optimization of One‐shot T1 imaging
Longitudinal relaxation times (T1) can be measured rapidly in an imaging context using a “one‐shot” method based on the pulse sequence originally proposed by D. Look and D. R. Locker, which is significantly faster than either repeated inversion recovery or repeated saturation recovery methods.
Rapid magnetic resonance quantification on the brain: Optimization for clinical usage
The aim of the optimization was to achieve the optimal result for the quantification of magnetic resonance parameters within a clinically acceptable time, and it was shown that, using the approach of synthetic MRI, both accurate conventional contrast images and quantification maps can be generated based on the same scan.
Towards a Single-Sequence Neurologic Magnetic Resonance Imaging Examination: Multiple-Contrast Images From an IR TrueFISP Experiment
Perfectly registered images with any desired contrast based on T1, T2, and spin density, along with underlying quantitative maps, can be obtained using a single IR-TrueFISP sequence.
Quantitative magnetization transfer imaging using balanced SSFP
Short repetition times in combination with high signal‐to‐noise ratios make bSSFP an ideal candidate for the acquisition of high resolution isotropic quantitative MT maps, as for the human brain, within clinically feasible acquisition times.
Optimized balanced steady‐state free precession magnetization transfer imaging
A novel method to generate MTR maps using bSSFP image acquisitions is presented and factors that optimize and influence this contrast are discussed.
k‐Space weighted image contrast (KWIC) for contrast manipulation in projection reconstruction MRI
A novel technique for manipulating contrast in projection reconstruction MRI is described, implemented into a fast spin‐echo (FSE) sequence, and it is shown that multiple T2‐weighted images can be reconstructed from a single image data set.
Quantification of T2 in the abdomen at 3.0 T using a T2‐prepared balanced turbo field echo sequence
It was found from simulations that for normal conditions, including the flip angle in the fit improved the systematic errors due to radiofrequency pulse errors and noise in the results to less than 1% without significantly increasing the random errors.
Standardized, reproducible, high resolution global measurements of T1 relaxation metrics in cases of multiple sclerosis.
The metrics derived from the relaxation maps are reproducible and have been shown to be sensitive to qualitative and quantitative differences between subgroups of patients with multiple sclerosis and control participants, with strong statistical significance.