Ashrafullina, et al., Izv
- R. R. Shagidullin, V. E. Bel’skii, L. Kh
- Akad. Nauk SSSR, Ser. Khim., No. 11,
As is known [1, 2] dimephosphon is successfully used for the treatment of various disorders, which suggests that this compound influences the key points common in the main metabolic processes. This conclusion stimulates investigations aimed at elucidation of the universal mechanism of drug action at the molecular level. Based on an analysis of data on the effect of dimephosphon on the aggregation of thrombocytes and the functional-metabolic activity of leukocytes, it was suggested  that such a universal mechanism can be related to the drug effect on the relative content of calcium ions in the intraand extracellular medium. In recent years, experiments using direct measurement of the Ca ion dynamics in the intracell medium showed that DMP increases the level of calcium ions in the cell by stimulating their release from intracellular depots . In this context, we have studied the possibility that dimephosphon participates in the molecular biological processes via interaction with calcium ions and their environment.