IQGAP1 regulation and roles in cancer.

Abstract

IQGAP1 is a key mediator of several distinct cellular processes, in particular cytoskeletal rearrangements. Recent studies have implicated a potential role for IQGAP1 in cancer, supported by the over-expression and distinct membrane localisation of IQGAP1 observed in a range of tumours. IQGAP1 is thought to contribute to the transformed cancer cell… (More)
DOI: 10.1016/j.cellsig.2009.02.023

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