IQGAP1 and its binding proteins control diverse biological functions.

  title={IQGAP1 and its binding proteins control diverse biological functions.},
  author={Colin D White and Huseyin H Erdemir and David B Sacks},
  journal={Cellular signalling},
  volume={24 4},
IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to humans. The most extensively studied family member is the ubiquitously expressed scaffold protein IQGAP1, which participates in multiple essential aspects of mammalian biology. IQGAP1 mediates these effects by binding to and regulating the function of numerous interacting proteins. Over ninety proteins have been reported to associate with IQGAP1, either directly or as part of a larger complex. In this… CONTINUE READING

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