IQGAP1 Is Involved in Post-Ischemic Neovascularization by Regulating Angiogenesis and Macrophage Infiltration

@inproceedings{Urao2010IQGAP1II,
  title={IQGAP1 Is Involved in Post-Ischemic Neovascularization by Regulating Angiogenesis and Macrophage Infiltration},
  author={Norifumi Urao and Masooma Razvi and Jin Oshikawa and Ronald D. McKinney and Rupal Chavda and Wadie F. Bahou and Tohru Fukai and Masuko Ushio-Fukai},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Neovascularization is an important repair mechanism in response to ischemic injury and is dependent on inflammation, angiogenesis and reactive oxygen species (ROS). IQGAP1, an actin-binding scaffold protein, is a key regulator for actin cytoskeleton and motility. We previously demonstrated that IQGAP1 mediates vascular endothelial growth factor (VEGF)-induced ROS production and migration of cultured endothelial cells (ECs); however, its role in post-ischemic neovascularization is… CONTINUE READING

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