IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation

@article{Li2009IPS1IC,
  title={IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation},
  author={Haobo Li and Daisuke Fujikura and Tanenobu Harada and Jun Uehara and Toshihide Kawai and Shizuo Akira and John C. Reed and Atsushi Iwai and Tadaaki Miyazaki},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={1615-1621}
}
Detachment of adherent epithelial cells from the extracellular matrix induces apoptosis, a process known as anoikis. We have shown that DAP3 is critical for anoikis induction. However, the mechanism for anoikis induction mediated by DAP3 is still unclear. Here, we show that interferon-β promoter stimulator 1 (IPS-1) binds DAP3 and induces anoikis by caspase activation. Recently, IPS-1 has been shown to be critical for antiviral immune responses, although there has been no report of its function… CONTINUE READING

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