IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation

  title={IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation},
  author={Haobo Li and Daisuke Fujikura and Tanenobu Harada and Jun Uehara and Toshihide Kawai and Shizuo Akira and John C. Reed and Atsushi Iwai and Tadaaki Miyazaki},
  journal={Cell Death and Differentiation},
Detachment of adherent epithelial cells from the extracellular matrix induces apoptosis, a process known as anoikis. We have shown that DAP3 is critical for anoikis induction. However, the mechanism for anoikis induction mediated by DAP3 is still unclear. Here, we show that interferon-β promoter stimulator 1 (IPS-1) binds DAP3 and induces anoikis by caspase activation. Recently, IPS-1 has been shown to be critical for antiviral immune responses, although there has been no report of its function… CONTINUE READING

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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 1 Excerpt

Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2007
View 2 Excerpts

Essential role of IPS-1 in innate immune responses against RNA viruses

The Journal of experimental medicine • 2006
View 2 Excerpts

Identification and characterization of MAVS , a mitochondrial antiviral signaling protein that activates NFk B and IRF 3

K Takahashi, T Kawai, +3 authors S Akira
Cell • 2005

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