IPRO: an iterative computational protein library redesign and optimization procedure.

  title={IPRO: an iterative computational protein library redesign and optimization procedure.},
  author={Manish C Saraf and Gregory L. Moore and Nina M. Goodey and Vania Yu Cao and Stephen J Benkovic and Costas D. Maranas},
  journal={Biophysical journal},
  volume={90 11},
A number of computational approaches have been developed to reengineer promising chimeric proteins one at a time through targeted point mutations. In this article, we introduce the computational procedure IPRO (iterative protein redesign and optimization procedure) for the redesign of an entire combinatorial protein library in one step using energy-based scoring functions. IPRO relies on identifying mutations in the parental sequences, which when propagated downstream in the combinatorial… CONTINUE READING


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