IPRO: an iterative computational protein library redesign and optimization procedure.

@article{Saraf2006IPROAI,
  title={IPRO: an iterative computational protein library redesign and optimization procedure.},
  author={Manish C Saraf and Gregory L. Moore and Nina M. Goodey and Vania Yu Cao and Stephen J Benkovic and Costas D. Maranas},
  journal={Biophysical journal},
  year={2006},
  volume={90 11},
  pages={4167-80}
}
A number of computational approaches have been developed to reengineer promising chimeric proteins one at a time through targeted point mutations. In this article, we introduce the computational procedure IPRO (iterative protein redesign and optimization procedure) for the redesign of an entire combinatorial protein library in one step using energy-based scoring functions. IPRO relies on identifying mutations in the parental sequences, which when propagated downstream in the combinatorial… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 81 references

Computational challenges in combinatorial library design for protein engineering

  • G. L. Moore, C. D. Maranas
  • AIChE J
  • 2004
Highly Influential
3 Excerpts

CHARMM: The energy function and its parameterization with an overview of the program

  • A. D. MacKerell, B. Brooks, +4 authors M. Karplus
  • In The Encyclopedia of Computational Chemistry. R…
  • 1998
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…