IPF: new insight on pathogenesis and treatment

@article{Harari2010IPFNI,
  title={IPF: new insight on pathogenesis and treatment},
  author={Sergio Harari and Antonella Caminati},
  journal={Allergy},
  year={2010},
  volume={65}
}
To cite this article: Harari S, Caminati A. IPF: new insight on pathogenesis and treatment. Allergy 2010; 65: 537–553. 
[Idiopathic pulmonary fibrosis].
Idiopathic pulmonary fibrosis (IPF) is one of the multiple pathologies included in the large family of diffuse interstitial parenchymal lung diseases (IPD). The latter represent a large group ofExpand
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TLDR
A Nigerian patient with IPF is presented with a classical high-resolution CT features, managed in the authors' centre together with associated problems. Expand
Recent advances in managing idiopathic pulmonary fibrosis
TLDR
An overview of recent advances in managing patients with IPF is provided, with a particular focus on how to reach a diagnosis, manage comorbidities and lung transplantation, care for the non-pharmacological needs of patients, and address palliative care. Expand
Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-β1 pathway.
In this study, anti-IPF lead compounds 42 and 44, derived from natural sesquiterpene lactones Isoalantolactone and alantolactone, were discovered by screening from a high-throughput TGF-β1 reporterExpand
The effects of atorvastatin on the kidney injury in mice with pulmonary fibrosis
TLDR
The present study investigated the effects of atorvastatin on kidney injury in mice with pulmonary fibrosis (PF) and found that the drug acted as a ‘spatially aggregating agent’ to protect the kidney from injury. Expand
Evolution and treatment of idiopathic pulmonary fibrosis.
TLDR
This work assisted to the conceptual change of the pathogenic hypothesis that currently considers IPF as a primarily fibrotic driven disease. Expand
Transforming growth factor‐beta 1 in humidifier disinfectant‐associated children's interstitial lung disease
Humidifier disinfectant‐associated children's interstitial lung disease has an unpredictable clinical course with a high morbidity and mortality.
Idiopathic Pulmonary Fibrosis.
TLDR
The suspected causes and usual progression of IPF, diagnostic techniques, treatments, and prognosis are described. Expand
Pirfenidone: significant treatment effects in idiopathic pulmonary fibrosis
TLDR
There is now a more profound basis for offering IPF patients an evidence‐based evaluation and treatment, and pirfenidone is a small molecule with antifibrotic and some hydroxyl scavenger properties that has recently been approved in Europe and elsewhere. Expand
The pathogenesis of idiopathic pulmonary fibrosis
TLDR
It is shown that in the presence of persisting injurious pathways, or disrupted repair pathways, activated TGF-β can lead to enhanced epithelial apoptosis and epithelial-to-mesenchymal transition (EMT) as well as fibroblast, and fibrocyte, transformation into myofibroblasts which are resistant to apoptosis. Expand
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