IP3 receptor: localization to plasma membrane of T cells and cocapping with the T cell receptor.

@article{Khan1992IP3RL,
  title={IP3 receptor: localization to plasma membrane of T cells and cocapping with the T cell receptor.},
  author={Andleeb Khan and Joseph P. Steiner and Michael G. Klein and Martin F. Schneider and Solomon H Snyder},
  journal={Science},
  year={1992},
  volume={257 5071},
  pages={815-8}
}
Immune responses in lymphocytes require cellular accumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca(2+)-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that… CONTINUE READING
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