IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model.

@article{Li2017IP34KA,
  title={IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model.},
  author={Cecilia W. P. Li and Sophie Lev and Desmarini Desmarini and Keren Kaufman-Francis and Adolfo Saiardi and Ana Paula Guimar{\~a}es Silva and Joel P Mackay and Philip E. Thompson and Tania C Sorrell and Julianne Teresa Djordjevic},
  journal={Virulence},
  year={2017},
  volume={8 8},
  pages={
          1833-1848
        }
}
We previously identified a series of inositol polyphosphate kinases (IPKs), Arg1, Ipk1, Kcs1 and Asp1, in the opportunistic fungal pathogen Cryptococcus neoformans. Using gene deletion analysis, we characterized Arg1, Ipk1 and Kcs1 and showed that they act sequentially to convert IP3 to PP-IP5 (IP7), a key metabolite promoting stress tolerance, metabolic adaptation and fungal dissemination to the brain. We have now directly characterized the enzymatic activity of Arg1, demonstrating that it is… CONTINUE READING
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