IP 3-Dependent Ca 2+ Oscillations Switch into a Dual Oscillator Mechanism in the Presence of PLC-Linked Hormones

  title={IP 3-Dependent Ca 2+ Oscillations Switch into a Dual Oscillator Mechanism in the Presence of PLC-Linked Hormones},
  author={Paula J. Bartlett and Ielyaas Cloete and James Sneyd and Andrew P Thomas},
  journal={SSRN Electronic Journal},

Short-term high fat diet feeding of mice suppresses catecholamine-stimulated Ca2+ signalling in hepatocytes and intact liver

It is proposed that impaired Ca2+ signalling plays a key role in the earliest phases of the etiology of NAFLD, and is responsible for many of the ensuing metabolic and related dysfunctional outcomes at the cellular and whole tissue level.

Purinergic P2Y1 and P2Y2/4 receptors elicit distinct Ca2+ signaling patterns in hepatocytes via differential feedback regulation by Protein Kinase C

Extracellular nucleotides are key regulators of liver physiology. In primary rat hepatocytes, P2Y1 receptor (P2Y1R) activation by ADP generates cytosolic calcium ([Ca2+]c) oscillations with narrow



Role of elementary Ca2+ puffs in generating repetitive Ca2+ oscillations

The roles of puffs in determining the periodicity of global Ca2+ waves are investigated using video‐rate confocal imaging and photorelease of IP3 in Xenopus oocytes to identify specific ’focal‘ sites that preferentially entrain both the temporal frequency and spatial directionality of Ca2+.

Derivation of Ca2+ signals from puff properties reveals that pathway function is robust against cell variability but sensitive for control

  • K. ThurleyM. Falcke
  • Biology, Computer Science
    Proceedings of the National Academy of Sciences
  • 2010
A division of tasks between global feedbacks and local cluster properties that guarantees robustness of function while maintaining sensitivity of control of the average ISI is found.

A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.

  • G. D. De YoungJ. Keizer
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1992
A simplified kinetic model is constructed to describe the properties of the Ca2+ activation and inhibition of the inositol 1,4,5-trisphosphate (IP3) receptor in the endoplasmic reticulum and finds that it reproduces a variety of in vivo and in vitro experiments.

A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations.

It is shown that muscarinic receptor-mediated, long- period Ca2+ oscillations in pancreatic acinar cells depend on [IP3] oscillations, whereas short-period Ca2+, airway smooth muscle do not.

Imaging the hierarchical Ca2+ signalling system in HeLa cells.

The hierarchy of Ca2+ signalling events, from fundamental levels (blips) to intermediate levels (puffs) to Ca2- waves, is a prototype forCa2+ signal transduction for non‐excitable cells, and is also analogous to the Ca2+.

The Spatial Distribution of Inositol 1,4,5-Trisphosphate Receptor Isoforms Shapes Ca2+ Waves*

Findings provide evidence that the apical concentration of type II InsP3Rs is essential for the formation of Ca2+ waves in hepatocytes and the subcellular distribution of InsP1,4,5-trisphosphate receptor isoforms may critically determine the repertoire of spatial patterns ofCa2+ signals.

Calcium signaling in liver.