IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival

@inproceedings{Lunardi2014IP10CXCL10II,
  title={IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival},
  author={Serena Lunardi and Nigel Balfour Jamieson and Su Yin Lim and Kristin L. Griffiths and Manuela M Carvalho-Gaspar and Osama Al-Assar and Sabira Yameen and Ross C. Carter and C. J. Mckay and Gabriele Spoletini and Stefano D'Ugo and Michael A Silva and Owen J Sansom and K. P. Janssen and Ruth J. Muschel and Thomas Baptist Brunner},
  booktitle={Oncotarget},
  year={2014}
}
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic reaction driven by pancreatic stellate cells (PSCs) that contributes to tumor progression. Here we sought to characterize the interactions between pancreatic cancer cells (PCCs) and PSCs that affect the inflammatory and immune response in pancreatic tumors. Conditioned media from mono- and cocultures of PSCs and PCCs were assayed for expression of cytokines and growth factors. IP-10/CXCL10 was the most highly… CONTINUE READING
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